04 // DOSES USED IN MICE
MOTS-c peptide dose figures came from animal tests
The amounts, shots, and timing below all came from tests with mice; they don’t guide treatment for a person, and no sound human plan exists.
What the mouse amounts cannot tell you
All figures here belong to tests using mice or dish-grown cells. The figures show how researchers ran each test, but they can’t be turned into an amount checked for your body. Researchers also haven’t timed how fast the human body removes MOTS-c from blood. There is no tested human amount or schedule.
What amounts researchers gave mice
Mouse studies used about 0.5 to 15 milligrams for each kilogram each day. In 2015, one study gave 0.5 milligram for each kilogram each day by an injection near the belly organs for about eight weeks [1]. Over seven days, a short test used 5 milligrams for each kilogram each day. Every figure belongs only to mice.
In 2021, mice aged 2, 12, and 22 months got 15 milligrams for each kilogram each day or 15 milligrams per kilogram on three days each week in that exercise study [2]. A 2016 bone study used 5 milligrams for each kilogram each day for 12 weeks in mice without ovaries [7]. The mouse shot methods and timing came from separate tests. None of these animal amounts can be carried over to a person [4].
A milligram is a small unit of weight, and each amount rose with the weight of the mouse [4]. Mice may handle and clear a substance quite differently from your body. Lower amounts appeared in longer sugar tests [1], while the higher amount was used for exercise [2]. Each figure answered one mouse question; none was picked for you.
Where researchers put the mouse shots
Most mouse studies put the shot near the belly organs. Researchers used that route in tests of sugar, exercise, bone, and cell repair [1][2][7][14]. Some work placed an injection under the skin, while cell studies added MOTS-c to a dish [3]. None of these methods finds a safe place on your body.
Some lab teams attached extra material to MOTS-c so cells in a dish would take it in more easily. That changed version wasn’t the same as plain MOTS-c used in the mouse shot tests. It doesn’t establish a safe human route for MOTS-c. No published human test has settled that question.
What a MOTS-c shot meant in these tests
Most papers placed a MOTS-c shot near a mouse’s belly organs [1][2]. A few lab tests used an injection under the skin. The papers give no tested human method [4]. A mouse route can’t name a safe place for you.
What the papers say about time in blood
No research team has timed MOTS-c in a person’s blood. Animal work used a shot each day or on three set days each week [2]. That plan helped researchers run the mouse tests. It doesn’t reveal how long MOTS-c would stay in you.
The mouse papers repeated shots each day or on three days per week [1][2][7]. Your kidneys help clear many small proteins from blood fairly fast. That general fact can’t replace a human blood test for MOTS-c. No one knows its time in human blood.
Some lab teams attached extra material to MOTS-c so cells would take it in more easily [4]. Those changed forms can’t tell you how fast your body clears plain MOTS-c. They also don’t supply a time for human blood. If someone gives you a firm figure, these papers don’t support it [4].
What the mouse plans leave unknown for you
For lab tests, MOTS-c often arrived as a freeze-dried powder [4]. The papers don’t give one shared recipe for adding liquid or storing the mixture; each test set its own steps. There’s no standard product for a person. Lab goods may differ in contents and germs.
In human work, researchers checked only the MOTS-c each person’s body produced. Children with obesity had lower blood levels, and other work found links with insulin response and exercise [10]. In people on dialysis, higher levels were tied to more deaths and heart problems. Nobody in these studies received the mouse amounts listed here.
What the mouse shot schedules were
There’s no human schedule [4]. Mouse work used a shot each day or on three set days per week. One test used 15 milligrams for each kilogram each day or 15 milligrams per kilogram on 3 days each week [2]. Those plans can’t give you a schedule.
What the studies say about a shot site
Researchers used the belly area in mice and, in some work, injections under the skin [1][2]. They weren’t comparing the safest places on a person. Researchers haven’t tested any shot site in people. These studies can’t supply one.
What daily shots meant in mouse tests
Some tests gave mice a shot every day [1][2]. Daily use was part of how researchers ran those tests. It doesn’t create a human schedule [4]. Animal work can’t show whether daily use would be safe for your body.
How long the mouse tests lasted
There’s no known length of human treatment [4]. One mouse test lasted about 8 weeks [1]. A bone test lasted 12 weeks [7]. Those spans can’t set a safe length for you.