About This Project
MOTS-c Chemical is an independent editorial project that publishes summaries of the peer-reviewed research literature on MOTS-c — the mitochondrial-derived peptide encoded by the mitochondrial 12S rRNA gene (MT-RNR1).
We are not a clinic. We do not employ clinicians and we do not provide medical advice. We do not manufacture, sell, or distribute any product. Our work is editorial commentary on publicly available science.
The name "MOTS-c Chemical" reflects our editorial position relative to the compound: this is a research chemical in every jurisdiction. The "chemical" in the name is a descriptor — not a vendor category and not a marketplace. Nothing is for sale here.
What We Publish
MOTS-c is a 16-amino-acid mitochondrial-derived peptide with a growing body of peer-reviewed research. As of 2025, the record includes foundational metabolic studies (Lee 2015, Cell Metabolism[1]), an exercise physiology and aging paper (Reynolds 2021, Nature Communications[2]), a nuclear-translocation mechanism study (Kim 2018, Cell Metabolism[4]), and a series of 2023–2026 publications identifying CK2alpha as a direct binding target[12], TRIM72-mediated membrane repair[15], cardiac protection in a diabetic model[11], and human-myotube atrophy prevention.[13]
We summarize what the studies actually measured. Doses are reported as administered in the relevant animal model or cell line. Quantitative claims carry numbered citations. We do not extrapolate animal findings to human recommendations.
PROHIBITED IN SPORT
Standing Regulatory Status
MOTS-c is prohibited under WADA S4.4.1. It has no FDA-approved indication. These are standing facts reported on every relevant page of this site.
Editorial Standards
Every quantitative claim in this digest is cited to a peer-reviewed source. Citations include DOI and PubMed URL for independent verification. We do not publish claims that are not supported by our citation record.
We do not link to vendors, recommend doses, or provide consultation. If you are considering administering any peptide compound, consult a licensed healthcare provider.
For the MOTS-c dosage record, the MOTS-c side effects page, and the complete frequently asked questions, all content reflects the published research record as of 2025.